Switch medication from tranylcypromine to vortioxetine.
Stop tranylcypromine
-
Day 1-14: decrease the original dose with about 25% every 3 days.
Start vortioxetine
- A wash-out period of two weeks is necessary.
-
Day 28: start administration of vortioxetine in a normal dosage of 10 mg/day. [1]
Cave
- Occurrence of the serotonin syndrome is possible without a wash-out period.
More information
- After the last dose of tranylcypromine it takes about 14 days to restore the activity of the MAO enzymes
-
↑ KNMP; Informatorium Medicamentorum 2015; Monografie "tranylcypromine" (Dutch)
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