Amitriptyline-dosulepine

Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline
dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin

Switch medication from amitriptyline to dosulepine.

Nietinrijdenbord.png Stop amitriptyline
  • Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start dosulepine
  • No wash-out period is needed.
  • Increase with about 25% of target dose per 3 days.
Infobord.png More information
  • Both drugs are a TCA with anticholinergic properties, so a switch to a relatively high starting dose can be made.
  • Plasma monitoring for TCA's is advisable, because of plasma-reponse relations, genetic polymorphism and under or overdosing.[3]
  1. ↑ 1.01.11.21.31.4 KNMP; Informatorium Medicamentorum 2015; Monografie "dosulepine" (Dutch)
  2. ↑ NVZA; Toxicology.org; Monografie 63 (dutch)
  3. ↑ (dutch) monografie.org tricyclische-antidepressiva
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